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(2, 28) Recent clinical data further emphasize lutein’s value in advanced AMD cases, where long-term supplementation contributes to increased MPOD and measurable improvements in visual acuity

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Although other GST classes do not appear to be compensating for GSTK1-1 deficiency, it is notable that tissues from heterozygous mice ( Gstk1 +/− ) mice showed similar levels of GSTK1-1 protein to WT mice (data not shown), suggesting that expression is elevated from the single gene copy in the heterozygous mice to maintain GSTK1-1 protein at WT levels